Studies on melanotropin (MSH) receptors of melanophores and melanoma cells.
نویسنده
چکیده
Rodnight, R. (1978) f n t . Rev. Biochem. 26, 1-80 Salmon, D. M., Fatih, S. & Schulster, D. (1981) Biochem. SOC. Trans. Schulster, D. & Jenner, C. (1975)J. Steroid Biochem. 6,389-394 Natl. Acad. Sci. U S A . 16, 1896-1900 Schulster, D. & Schwyzer, R. (1980) in Cellular Receptors for Hormones and Neurotransmitters (Schulster, D. & Levitski, A., eds.), pp. 197-217, Wiley and Sons, Chichester and New York 9.96-97
منابع مشابه
Melanotropin receptors demonstrated in situ in human melanoma.
Although some cultured human melanoma cell lines are responsive to melanotropins (melanocyte-stimulating hormones [MSH]), the prevalence and tissue distribution of MSH receptors in melanoma are unknown. We report here the use of an in situ binding technique to demonstrate specific MSH receptors in surgical specimens of human melanoma. The distribution and binding properties of specific MSH bind...
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Melanophore-stimulating hormone (MSH) release from the pars intermedia of the pituitary gland is probably regulated by multiple factors of hypothalamic origin. We have examined a number of potential regulatory factors for their effects on MSH release from the amphibian Xenopus laevis. Serotonin and acetylcholine have no effect on MSH release. Both adrenaline and noradrenaline inhibit release of...
متن کاملThe Value of Technetium-99m Labeled Alpha-Melanocyte- Stimulating Hormone (99mTc-α-MSH) in Diagnosis of Primary and Metastatic Lesions of Malignant Melanoma
Objective(s): Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes overexpressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic...
متن کاملDesign and characterization of alpha-melanotropin peptide analogs cyclized through rhenium and technetium metal coordination.
alpha-Melanocyte stimulating hormone (alpha-MSH) analogs, cyclized through site-specific rhenium (Re) and technetium (Tc) metal coordination, were structurally characterized and analyzed for their abilities to bind alpha-MSH receptors present on melanoma cells and in tumor-bearing mice. Results from receptor-binding assays conducted with B16 F1 murine melanoma cells indicated that receptor-bind...
متن کاملA 99mTc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging
Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 9 1 شماره
صفحات -
تاریخ انتشار 1981